Comparative, genome-scale transcriptional analysis of CHRF-288-11 and primary human megakaryocytic cell cultures provides novel insights into lineage-specific differentiation.

doi:10.1016/j.exphem.2006.10.017

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Article

Comparative, genome-scale transcriptional analysis of CHRF-288-11 and primary human megakaryocytic cell cultures provides novel insights into lineage-specific differentiation.

Experimental hematology - 1 Mar 2007

Fuhrken Peter G, Chen Chi, Miller William M, Papoutsakis Eleftherios T

Abstract excerpt

OBJECTIVES: Little is known about the transcriptional events underlying megakaryocytic (Mk) differentiation. We sought to identify genes and pathways previously unassociated with megakaryopoiesis and to evaluate the CHRF-288-11 (CHRF) megakaryoblastic cell line as a model system for investigating megakaryopoiesis. METHODS: Using DNA microarrays, Q-RT-PCR, and protein-level assays, we compared the dynamic gene...

Topics

Apoptosis
Cell Cycle
Cell Differentiation
Cell Line
Cell Lineage
Cells, Cultured
Cluster Analysis
Flow Cytometry
GTPase-Activating Proteins
Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome

Humans

Megakaryocytes

Mitosis

Oligonucleotide Array Sequence Analysis

Phenotype

Receptors, G-Protein-Coupled

Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 17309828
DOI: 10.1016/j.exphem.2006.10.017

Genes

BBC3
JAK2

Provenance

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