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Article

Negative regulation of globin gene expression during megakaryocytic differentiation of a human erythroleukemic cell line.

Molecular and cellular biology - 1 Jul 1991

Lumelsky N L, Forget B G

Abstract excerpt

The human erythroleukemic cell line K562 was used as a model for analysis of the mechanisms responsible for alterations in gene expression during differentiation. K562 cells normally synthesize fetal hemoglobin (gamma-globin), but treatment with tumor-promoting phorbol esters (phorbol myristate acetate and tetradecanoyl phorbol acetate) results in the loss of the erythroid phenotype of the cells and causes a...

Topics

Cell Differentiation
Cell Nucleus
Gene Expression Regulation, Neoplastic
Globins
Humans
Leukemia, Erythroblastic, Acute
Megakaryocytes
Phenotype
Plasmids
RNA, Messenger
RNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Restriction Mapping

Tetradecanoylphorbol Acetate

Transcription, Genetic

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 2046667
DOI: 10.1128/mcb.11.7.3528-3536.1991
PMCID: PMC361092

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2046667-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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