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Article

Negative regulation of globin gene expression during megakaryocytic differentiation of a human erythroleukemic cell line.

Molecular and cellular biology - 1 Jul 1991

Lumelsky N L, Forget B G

Abstract excerpt

The human erythroleukemic cell line K562 was used as a model for analysis of the mechanisms responsible for alterations in gene expression during differentiation. K562 cells normally synthesize fetal hemoglobin (gamma-globin), but treatment with tumor-promoting phorbol esters (phorbol myristate acetate and tetradecanoyl phorbol acetate) results in the loss of the erythroid phenotype of the cells and causes a...

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Identifiers

PMID: 2046667
DOI: 10.1128/mcb.11.7.3528-3536.1991
PMCID: PMC361092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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