Article
A potential role for protein kinase C-epsilon in regulating megakaryocytic lineage commitment.
The Journal of biological chemistry - 5 Jan 2001
Racke F K, Wang D, Zaidi Z, Kelley J, Visvader J, Soh J W, Goldfarb A N
Abstract excerpt
Multiple studies have shown that intracellular signal transduction by the protein kinase C (PKC) family participates in the initiation of megakaryocyte differentiation. In this study, multiple approaches addressed the functional contributions by specific PKC isozymes to megakaryocytic lineage commitment of two independent cell lines, K562 and human erythroleukemia (HEL). Pharmacologic profiles of induction and...
Topics
- Carbazoles
- Cell Differentiation
- Cell Lineage
- Culture Media, Conditioned
- DNA-Binding Proteins
- Diterpenes
- Erythroid-Specific DNA-Binding Factors
- Fluorescent Antibody Technique
- GATA1 Transcription Factor
- Gene Expression Regulation
- Genes, Reporter
- Humans
- Indoles