Article
Regulation of megakaryocyte phenotype in human erythroleukemia cells.
The Journal of clinical investigation - 1 Apr 1990
Long M W, Heffner C H, Williams J L, Peters C, Prochownik E V
Abstract excerpt
Induction of human erythroleukemia (HEL) cells with nanomolar tumor-promoting phorbol myristate acetate (PMA) diesters results in the synchronous acquisition of multiple markers of the megakaryocyte phenotype. Induced cells markedly increase their content of cytoplasm and show features of morphol...
Topics
- Antigens
- Cell Differentiation
- Cell Division
- Cell Fusion
- Humans
- Interphase
- Leukemia, Erythroblastic, Acute
- Megakaryocytes
- Phenotype
- Phorbol 12,13-Dibutyrate
- Protein Kinase C
- Proto-Oncogene Mas
- Proto-Oncogenes
- Tetradecanoylphorbol Acetate
- Tumor Cells, Cultured