Regulation of c-Myc and Max in megakaryocytic and monocytic-macrophagic differentiation of K562 cells induced by protein kinase C modifiers: c-Myc is down-regulated but does not inhibit differentiation.

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Regulation of c-Myc and Max in megakaryocytic and monocytic-macrophagic differentiation of K562 cells induced by protein kinase C modifiers: c-Myc is down-regulated but does not inhibit differentiation.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Sept 1999

Lerga A, Crespo P, Berciano M, Delgado M D, Cañelles M, Calés C, Richard C, Ceballos E, Gutierrez P, Ajenjo N, Gutkind S, León J

Abstract excerpt

We have studied the regulation and role of c-Myc and Max in the differentiation pathways induced in K562 cells by 12-O-tetradecanoyl phorbol-13 acetate (TPA) and staurosporine, an activator and inhibitor, respectively, of protein kinase C (PKC). We found that staurosporine induced megakaryocytic differentiation, as revealed by the cellular ultrastructure, platelet formation, and DNA endoreduplication. In...

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PMID: 10511314

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