Article
p53-mediated differentiation of the erythroleukemia cell line K562.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Jun 2000
Chylicki K, Ehinger M, Svedberg H, Bergh G, Olsson I, Gullberg U
Abstract excerpt
The tumor suppressor gene p53 can mediate both apoptosis and cell cycle arrest. In addition, p53 also influences differentiation. To further characterize the differentiation inducing properties of p53, we overexpressed a temperature-inducible p53 mutant (ptsp53Val135) in the erythroleukemia cell line K562. The results show that wild-type p53 and hemin synergistically induce erythroid differentiation of K562...
Topics
- Animals
- Antigens, CD
- Benzidines
- Blotting, Western
- Cell Cycle
- Cell Death
- Cell Differentiation
- Cell Separation
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA, Complementary
- Dose-Response Relationship, Drug
- Flow Cytometry