Regulation of T cell receptor (TCR)-beta locus allelic exclusion and initiation of TCR-alpha locus rearrangement in immature thymocytes by signaling through the CD3 complex.

doi:10.1002/eji.1830250519

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Article

Regulation of T cell receptor (TCR)-beta locus allelic exclusion and initiation of TCR-alpha locus rearrangement in immature thymocytes by signaling through the CD3 complex.

European journal of immunology - 1 May 1995

Levelt C N, Wang B, Ehrfeld A, Terhorst C, Eichmann K

Abstract excerpt

During thymocyte differentiation, the T cell receptor (TCR)-beta genes are rearranged before the TCR-alpha genes. Immature CD4-8- double-negative thymocytes with a productive rearrangement of the TCR-beta locus are selected to continue maturation to the CD4+8+ double-positive stage, driven by signals through the pre-TCR. The signals through the pre-TCR can be synchronized by injection of mice with anti-CD3...

Topics

Alleles
Animals
Animals, Newborn
Base Sequence
Cell Differentiation
DNA-Binding Proteins
Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Homeodomain Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocytes, Null

Mice

Mice, Inbred C57BL

Molecular Sequence Data

Muromonab-CD3

Polymerase Chain Reaction

Protein Biosynthesis

Proteins

Receptor-CD3 Complex, Antigen, T-Cell

Source

Open in PubMed

Identifiers

PMID: 7774628
DOI: 10.1002/eji.1830250519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7774628-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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