Article
T cell development in mice that lack the zeta chain of the T cell antigen receptor complex.
Science (New York, N.Y.) - 13 Aug 1993
Love P E, Shores E W, Johnson M D, Tremblay M L, Lee E J, Grinberg A, Huang S P, Singer A, Westphal H
Abstract excerpt
The zeta subunit of the T cell antigen receptor complex is required for targeting nascent receptor complexes to the cell surface and for receptor-mediated signal transduction. To examine the significance of the zeta subunit in T cell development, mice deficient for zeta expression were generated...
Topics
- Animals
- Antigens, CD
- CD3 Complex
- CD4 Antigens
- CD5 Antigens
- CD8 Antigens
- Cell Differentiation
- Membrane Proteins
- Mice
- Mutation
- RNA, Messenger
- Receptors, Antigen, T-Cell
- Receptors, Antigen, T-Cell, alpha-beta
- T-Lymphocyte Subsets
- Thymus Gland