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Article

Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease.

The Journal of experimental medicine - 24 Sept 2012

Hwang Sujin, Song Ki-Duk, Lesourne Renaud, Lee Jan, Pinkhasov Julia, Li Liqi, El-Khoury Dalal, Love Paul E

Abstract excerpt

Negative selection and regulatory T (T reg) cell development are two thymus-dependent processes necessary for the enforcement of self-tolerance, and both require high-affinity interactions between the T cell receptor (TCR) and self-ligands. However, it remains unclear if they are similarly impacted by alterations in TCR signaling potential. We generated a knock-in allele (6F) of the TCR ζ chain gene encoding a...

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Identifiers

PMID: 22945921
DOI: 10.1084/jem.20120058
PMCID: PMC3457736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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