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Article

T cell development in mice lacking all T cell receptor zeta family members (Zeta, eta, and FcepsilonRIgamma).

The Journal of experimental medicine - 6 Apr 1998

Shores E W, Ono M, Kawabe T, Sommers C L, Tran T, Lui K, Udey M C, Ravetch J, Love P E

Abstract excerpt

The zeta family includes zeta, eta, and FcepsilonRIgamma (Fcgamma). Dimers of the zeta family proteins function as signal transducing subunits of the T cell antigen receptor (TCR), the pre-TCR, and a subset of Fc receptors. In mice lacking zeta/eta chains, T cell development is impaired, yet low numbers of CD4+ and CD8+ T cells develop. This finding suggests either that pre-TCR and TCR complexes lacking a zeta...

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Identifiers

PMID: 9529325
DOI: 10.1084/jem.187.7.1093
PMCID: PMC2212212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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