Article
Disruption of the Golgi apparatus by brefeldin A inhibits the cytotoxicity of ricin, modeccin, and Pseudomonas toxin.
Experimental cell research - 1 Feb 1991
Yoshida T, Chen C C, Zhang M S, Wu H C
Abstract excerpt
We have studied the cytotoxicity of ricin in cells treated with brefeldin A (BFA), which dramatically disrupts the structure of the Golgi apparatus causing Golgi content and membrane to redistribute to the ER. BFA inhibits the cytotoxicity of ricin in Chinese hamster ovary, normal rat kidney, and...
Topics
- ADP Ribose Transferases
- Alkaloids
- Ammonium Chloride
- Animals
- Bacterial Toxins
- Brefeldin A
- Cell Line
- Cyclopentanes
- Cytotoxins
- Endocytosis
- Exotoxins
- Golgi Apparatus
- Kinetics
- Lectins
- Mutation
- Plant Lectins
- Ribosome Inactivating Proteins, Type 2
- Ricin