Article
Distant metastases in ovarian cancer: association with p53 mutations.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 1999
Sood A K, Sorosky J I, Dolan M, Anderson B, Buller R E
Abstract excerpt
Distant metastases are unusual occurrences at presentation and during the progression of epithelial ovarian cancer. There are no good clinical predictors of this phenomenon. Because p53 dysfunction is common in ovarian cancer, we chose to investigate whether specific types of mutations predicted a predisposition to distant metastasis. We hypothesized that the complete absence of intact p53 protein as seen with...
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