Article
Heterogeneity within and between primary colorectal carcinomas and matched metastases as revealed by analysis of Ki-ras and p53 mutations.
Biochemical and biophysical research communications - 17 Dec 2004
Albanese Ida, Scibetta Angelo Giuseppe, Migliavacca Manuela, Russo Antonio, Bazan Viviana, Tomasino Rosa Maria, Colomba Paolo, Tagliavia Marcello, La Farina Mario
Abstract excerpt
Analysis of the genetic status of Ki-ras and p53 in primary colorectal carcinomas and matched colorectal liver metastasis from 30 patients reveals an overall heterogeneity both within and between the two tumoral tissues. Both genes were found mutated with a similar frequency in both tissues; however, identical mutations in primary tumor and matched metastasis were found less frequently in the case of the Ki-ras...
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