Article
Heterogeneity in p53 mutations in mouse mammary tumor subpopulations with different metastatic potential from the orthotopic site.
Anticancer research - 1 Jan 2000
Shekhar P V, Werdell J, Christman J K, Miller F R
Abstract excerpt
We have found that p53 expression is altered with progression to the metastatic phenotype of a series of neoplastic subpopulations of a single mouse mammary tumor. Single strand conformation polymorphism (SSCP) analysis of p53 transcripts indicate that the expressed p53 genes in each of the subpo...
Topics
- Animals
- Base Sequence
- DNA Primers
- DNA Restriction Enzymes
- Genes, p53
- Mammary Neoplasms, Experimental
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Molecular Sequence Data
- Mutation
- Neoplasm Metastasis
- Polymerase Chain Reaction
- Restriction Mapping