Article
Characterization of p53 mutations in colorectal liver metastases and correlation with clinical parameters.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 1999
Tullo A, D'Erchia A M, Honda K, Mitry R R, Kelly M D, Habib N A, Saccone C, Sbisà E
Abstract excerpt
The presence and type of mutations of the p53 tumor suppressor gene were determined in 40 patients undergoing curative hepatic resection for metastatic colorectal carcinoma. This represents the largest series in the literature on the screening of p53 mutations for liver metastases. The analysis was performed in exons 5-9 by denaturing gradient gel electrophoresis followed by direct sequencing. Forty-five percent...
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