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Article

The <i>Caenorhabditis elegans</i> gene <i>unc-76</i> and its human homologs define a new gene family involved in axonal outgrowth and fasciculation

1 Apr 1997

Abstract excerpt

The gene unc-76 (unc, uncoordinated) is necessary for normal axonal bundling and elongation within axon bundles in the nematode Caenorhabditis elegans. The UNC-76 protein and two human homologs identified as expressed sequence tags are not similar to previously characterized proteins and thus represent a new protein family. At least one of these human homologs can function in C. elegans, suggesting that it, like...

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PMID: 9096408
DOI: 10.1073/pnas.94.7.3414

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Related research

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Research trail→

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The <i>Caenorhabditis elegans</i> gene <i>unc-76</i> and its human homologs define a new gene family involved in axonal outgrowth and fasciculationPMID 9096408Read ↗

Genes necessary for directed axonal elongation or fasciculation in C. elegans.Semantic proximity Read ↗

Axon guidance genes identified in a large-scale RNAi screen using the RNAi-hypersensitive Caenorhabditis elegans strain nre-1(hd20) lin-15b(hd126).Semantic proximity Read ↗

UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans.Semantic proximity Read ↗

UNC-115, a conserved protein with predicted LIM and actin-binding domains, mediates axon guidance in C. elegans.Semantic proximity Read ↗

The kinesin-associated protein UNC-76 is required for axonal transport in the Drosophila nervous system.Semantic proximity Read ↗

UNC-16 alters DLK-1 localization and negatively regulates actin and microtubule dynamics in Caenorhabditis elegans regenerating neurons.Semantic proximity Read ↗

ENU-3 is a novel motor axon outgrowth and guidance protein in C. elegans.Semantic proximity Read ↗

Regulatory machinery of UNC-33 Ce-CRMP localization in neurites during neuronal development in Caenorhabditis elegans.Semantic proximity Read ↗

An UNC-40 pathway directs postsynaptic membrane extension in Caenorhabditis elegans.Semantic proximity Read ↗

Neuronal migrations and axon fasciculation are disrupted in ina-1 integrin mutants.Semantic proximity Read ↗

Axon development is regulated at genetic and proteomic interfaces between the integrin adhesome and the RPM-1 ubiquitin ligase signaling hubSemantic proximity Read ↗

Axon guidance mechanisms in Caenorhabditis elegans.Semantic proximity Read ↗

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