Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Axon guidance mechanisms in Caenorhabditis elegans.

Current opinion in genetics & development - 1 Aug 1994

Culotti J G

Abstract excerpt

Genetic studies have identified an extracellular path cue molecule, UNC-6, and a neuronal receptor, UNC-5, that act to guide migrating pioneer growth cones along the dorsoventral coordinate of the Caenorhabditis elegans body wall. Ectopic expression studies and characterization of mutants have demonstrated directly the instructive action of these molecules, suggesting a molecular model for how they perform their...

Read the complete abstract on PubMed

Topics

Animals
Axons
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Movement
Cell Polarity
Chemotactic Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Embryo, Nonmammalian

Gene Expression Regulation, Developmental

Helminth Proteins

Membrane Proteins

Mutation

Nerve Growth Factors

Nerve Tissue Proteins

Netrins

Neural Pathways

Receptors, Cell Surface

Receptors, Growth Factor

Source

Identifiers

PMID: 7950328
DOI: 10.1016/0959-437x(94)90077-g

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Axon guidance mechanisms in Caenorhabditis elegans.PMID 7950328Read ↗

Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans.Semantic proximity Read ↗

Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally.Semantic proximity Read ↗

Genetic analysis of growth cone migrations in Caenorhabditis elegans.Semantic proximity Read ↗

Extracellular matrix regulates UNC-6 (netrin) axon guidance by controlling the direction of intracellular UNC-40 (DCC) outgrowth activity.Semantic proximity Read ↗

UNC-6/netrin and its receptors UNC-5 and UNC-40/DCC modulate growth cone protrusion in vivo in C. elegans.Semantic proximity Read ↗

ENU-3 is a novel motor axon outgrowth and guidance protein in C. elegans.Semantic proximity Read ↗

Neurons refine the Caenorhabditis elegans body plan by directing axial patterning by Wnts.Semantic proximity Read ↗

Identification of domains of netrin UNC-6 that mediate attractive and repulsive guidance and responses from cells and growth cones.Semantic proximity Read ↗

The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans.Semantic proximity Read ↗

ENU-3 functions in an UNC-6/netrin dependent pathway parallel to UNC-40/DCC/frazzled for outgrowth and guidance of the touch receptor neurons in C. elegans.Semantic proximity Read ↗

UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans.Semantic proximity Read ↗

Domain-specific mutations in unc-6/Netrin differentially affect dorsal-ventral axon pathfinding in Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.