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Article

Axon guidance genes identified in a large-scale RNAi screen using the RNAi-hypersensitive Caenorhabditis elegans strain nre-1(hd20) lin-15b(hd126).

Proceedings of the National Academy of Sciences of the United States of America - 16 Jan 2007

Schmitz Caroline, Kinge Parag, Hutter Harald

Abstract excerpt

The navigation of axons toward their targets is a highly dynamic and precisely regulated process during nervous system development. The molecular basis of this navigation process is only partly understood. In Caenorhabditis elegans, we isolated the RNAi-hypersensitive strain nre-1(hd20) lin-15b(hd126), which allows us to phenocopy axon guidance defects of known genes by feeding RNAi. We used this mutant strain to...

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Identifiers

PMID: 17213328
DOI: 10.1073/pnas.0510527104
PMCID: PMC1783400

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