Article
Regulatory machinery of UNC-33 Ce-CRMP localization in neurites during neuronal development in Caenorhabditis elegans.
Journal of neurochemistry - 1 Dec 2005
Tsuboi Daisuke, Hikita Takao, Qadota Hiroshi, Amano Mutsuki, Kaibuchi Kozo
Abstract excerpt
In Caenorhabditis elegans, unc-33 encodes an orthologue of the vertebrate collapsin response mediator protein (CRMP) family. We previously reported that CRMP-2 accumulated in the distal part of the growing axon of vertebrate neurons and played critical roles in axon elongation. unc-33 mutants show axonal outgrowth defects in several neurons. It has been reported that UNC-33 accumulates in neurites, whereas a...
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