Article
UNC-115, a conserved protein with predicted LIM and actin-binding domains, mediates axon guidance in C. elegans.
Neuron - 1 Aug 1998
Lundquist E A, Herman R K, Shaw J E, Bargmann C I
Abstract excerpt
Axon guidance receptors modulate the growth cone cytoskeleton through signaling pathways that are not well understood. Here, we describe the C. elegans unc-115 gene, which encodes a candidate cytoskeletal linker protein that acts in axon guidance. unc-115 mutants have defects in a subset of axons...
Topics
- Amino Acid Sequence
- Animals
- Caenorhabditis elegans
- Conserved Sequence
- Culture Techniques
- Cytoskeletal Proteins
- Epidermis
- Genetic Code
- Helminth Proteins
- Humans
- LIM Domain Proteins
- Microfilament Proteins
- Molecular Sequence Data
- Morphogenesis
- Mutation
- Nerve Tissue Proteins
- Neurons
- Protein Structure, Tertiary