Article

Axon development is regulated at genetic and proteomic interfaces between the integrin adhesome and the RPM-1 ubiquitin ligase signaling hub

2023-11-15

Abstract excerpt

<h4>SUMMARY</h4> Integrin signaling plays important roles in development and disease. An adhesion signaling network called the integrin adhesome has been principally defined using bioinformatics and proteomics. To date, the adhesome has not been studied using integrated proteomic and genetic approaches. Here, proteomic studies in C. elegans identified physical associations between the RPM-1 ubiquitin ligase sign...

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Literature Corpus work: 8ea40217-a68e-5720-a950-97310c70ba34
DOI: 10.1101/2023.11.15.566604

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