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Article

UNC-16 alters DLK-1 localization and negatively regulates actin and microtubule dynamics in Caenorhabditis elegans regenerating neurons.

Genetics - 5 Nov 2021

Kulkarni Sucheta S, Sabharwal Vidur, Sheoran Seema, Basu Atrayee, Matsumoto Kunihiro, Hisamoto Naoki, Ghosh-Roy Anindya, Koushika Sandhya P

Abstract excerpt

Neuronal regeneration after injury depends on the intrinsic growth potential of neurons. Our study shows that UNC-16, a Caenorhabditis elegans JIP3 homolog, inhibits axonal regeneration by regulating initiation and rate of regrowth. This occurs through the inhibition of the regeneration-promoting activity of the long isoform of DLK-1 and independently of the inhibitory short isoform of DLK-1. We show that UNC-16...

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PMID: 34740241
DOI: 10.1093/genetics/iyab139
PMCID: PMC8570795

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Source receipt: pubmed, retrieved 7 Sept 2026.

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