Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced expression of pax-3 is associated with overexpression of cdc46 in the mouse embryo.

Development genes and evolution - 1 May 1998

Hill A L, Phelan S A, Loeken M R

Abstract excerpt

CDC46/MCM5 encodes a protein that is highly conserved among yeast, plants, and animals. It is found in a complex which exhibits DNA replication licensing activity, which is proposed to regulate the synthesis of DNA once and only once per cell cycle. In yeast, loss of function mutations of CDC46/MCM5 decrease DNA synthesis. Very little is known about the regulation of CDC46/MCM5 in any species. We report here...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mice
Share to Alleles
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to In Situ Hybridization

Share to Mice, Inbred C57BL

Share to Polymerase Chain Reaction

Share to Transcription Factors

Source

Identifiers

PMID: 9601985
DOI: 10.1007/s004270050163

Genes

MCM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced expression of pax-3 is associated with overexpression of cdc46 in the mouse embryo.PMID 9601985Read ↗

Requirement of CDC45 for postimplantation mouse development.Semantic proximity Read ↗

mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p.Semantic proximity Read ↗

Cell proliferation and DNA replication defects in a Drosophila MCM2 mutant.Semantic proximity Read ↗

Mutations in CDC45, Encoding an Essential Component of the Pre-initiation Complex, Cause Meier-Gorlin Syndrome and Craniosynostosis.Semantic proximity Read ↗

Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency.Semantic proximity Read ↗

The fertilization-induced DNA replication factor MCM6 of maize shuttles between cytoplasm and nucleus, and is essential for plant growth and development.Semantic proximity Read ↗

Depletion of minichromosome maintenance protein 5 in the zebrafish retina causes cell-cycle defect and apoptosis.Semantic proximity Read ↗

CDC46/MCM5, a yeast protein whose subcellular localization is cell cycle-regulated, is involved in DNA replication at autonomously replicating sequences.Semantic proximity Read ↗

High abundance of CDC45 inhibits cell proliferation through elevation of HSPA6Semantic proximity Read ↗

Requirement for the c-Maf transcription factor in crystallin gene regulation and lens developmentSemantic proximity Read ↗

Developmental roles of the Mi-2/NURD-associated protein p66 in Drosophila.Semantic proximity Read ↗

Functional analysis of an Orc6 mutant in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.