Article
Direct identification of base-paired RNA nucleotides by correlated chemical probing.
RNA (New York, N.Y.) - 1 Jan 2017
Krokhotin Andrey, Mustoe Anthony M, Weeks Kevin M, Dokholyan Nikolay V
Abstract excerpt
Many RNA molecules fold into complex secondary and tertiary structures that play critical roles in biological function. Among the best-established methods for examining RNA structure are chemical probing experiments, which can report on local nucleotide structure in a concise and extensible manner. While probing data are highly useful for inferring overall RNA secondary structure, these data do not directly...
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