Article
Adenosine-to-inosine RNA editing: perspectives and predictions.
Mini reviews in medicinal chemistry - 1 Nov 2006
Hoopengardner Barry
Abstract excerpt
Adenosine-to-Inosine RNA editing introduces changes in RNA transcripts via a post-transcriptional mechanism, the hydrolytic deamination of adenosine (A) to inosine (I) which is interpreted as guanosine by cellular machineries. Adenosine deaminases that act on RNA (ADAR) enzymes catalyze editing in double-stranded (ds) RNA substrates.
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