Article
Two universally conserved adenosines of the group I intron that are important for self-splicing but not for core catalytic activity.
Journal of biochemistry - 1 Jan 1994
Williams K P, Fujimoto D N, Inoue T
Abstract excerpt
Two adenosine residues, universally conserved among group I introns, are located in the L4 region of the catalytic core. Base-substitution mutations in these adenosines resulted in diminished in vitro self-splicing activity of the Tetrahymena group I intron, more severely for double than for sing...
Topics
- Adenosine
- Animals
- Base Sequence
- Catalysis
- Conserved Sequence
- Hydrolysis
- Introns
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- RNA, Catalytic
- RNA, Protozoan