Article
Nucleoside analog studies indicate mechanistic differences between RNA-editing adenosine deaminases.
Nucleic acids research - 1 Oct 2012
Mizrahi Rena A, Phelps Kelly J, Ching Andrea Y, Beal Peter A
Abstract excerpt
Adenosine deaminases acting on RNA (ADAR1 and ADAR2) are human RNA-editing adenosine deaminases responsible for the conversion of adenosine to inosine at specific locations in cellular RNAs. Since inosine is recognized during translation as guanosine, this often results in the expression of protein sequences different from those encoded in the genome. While our knowledge of the ADAR2 structure and catalytic...
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