Transcriptome-wide identification of adenosine-to-inosine editing using the ICE-seq method.

Abstract excerpt

Inosine (I), a modified base found in the double-stranded regions of RNA in metazoans, has various roles in biological processes by modulating gene expression. Inosine is generated from adenosine (A) catalyzed by ADAR (adenosine deaminase acting on RNA) enzymes in a process called A-to-I RNA editing. As inosine is converted to guanosine (G) by reverse transcription, the editing sites can be identified by simply...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adenosine
• Share to Biochemistry
• Share to DNA, Complementary