Regulation of interleukin-12 signalling during T helper phenotype development.

doi:10.1007/978-1-4615-5855-2_9

Back to search

Article

Regulation of interleukin-12 signalling during T helper phenotype development.

Advances in experimental medicine and biology - 1 Jan 1996

Jacobson N G, Szabo S J, Güler M L, Gorham J D, Murphy K M

Abstract excerpt

The experiments described above have allowed us to define the molecular events in IL-12 signalling. Within minutes after IL-12 treatment of responsive cells, Stat1, Stat3, and Stat4 are tyrosine phosphorylated. These molecules form nuclear DNA-binding complexes consisting of homodimeric Stat1 and...

Topics

Animals
Humans
Hypersensitivity, Immediate
Interleukin-12
Mice
Phenotype
Signal Transduction
T-Lymphocytes, Helper-Inducer

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.