Article

Molecular mechanisms of T helper 1 and T helper 2 cell development : differential signalling in response to Interleukin-12

1999-01-01

Abstract excerpt

Interleukin-12, a heterodimeric cytokine produced by activated monocytes and dendritic cells, plays a crucial role in regulating IFN-ү production and in the generation of IFN-ү producing T helper 1 cells. Here is shown that the IL-12Rß2 subunit, a recently cloned binding and signal transducing component of the IL- 12R, is expressed on human Thl but not Th2 clones, and is induced during differentiatio...

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Literature Corpus work: 9b0669c4-a271-5d43-8138-05740626218c
DOI: 10.21954/ou.ro.00010255

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