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Article

A heritable defect in IL-12 signaling in B10.Q/J mice. I. In vitro analysis.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2001

Ortmann R, Smeltz R, Yap G, Sher A, Shevach E M

Abstract excerpt

B10.Q mice are normally susceptible to the induction of collagen-induced arthritis. We noted that one subline of B10.Q mice, B10.Q/J, was completely resistant to disease induction when immunized with collagen in CFA. B10.Q/J mice have a global defect in the generation of Th1 responses, and Ag-specific T cells derived from this strain failed to produce IFN-gamma. Because T cells from these mice could produce...

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PMID: 11313413
DOI: 10.4049/jimmunol.166.9.5712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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