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Article

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice.

Nature - 11 Jul 1996

Kaplan M H, Sun Y L, Hoey T, Grusby M J

Abstract excerpt

Interactions between cytokine and receptor lead to the activation of multiple signalling molecules, including the family of signal transducer and activator of transcription (STAT) proteins. STAT4 is one member of this family, and is activated only in response to the cytokine interleukin (IL)-12 (refs 5, 6). By gene targeting, we have generated mice deficient in STAT4 to determine whether the function of this...

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Source

Identifiers

PMID: 8700209
DOI: 10.1038/382174a0

Genes

STAT4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice.PMID 8700209Read ↗

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STAT1β Is Not Dominant Negative and Is Capable of Contributing to Gamma Interferon-Dependent Innate ImmunitySemantic proximity Read ↗

Enteric pathogens and gut function: Role of cytokines and STATsSemantic proximity Read ↗

Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitisSemantic proximity Read ↗

Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitisSemantic proximity Read ↗

Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammationSemantic proximity Read ↗

Targeted disruption of the interferon-gamma receptor 2 gene results in severe immune defects in mice.Semantic proximity Read ↗

Disease Risk-Associated Genetic Variants in STAT1 and STAT4 Function in a Complementary Manner to Increase Pattern-Recognition Receptor-Induced Outcomes in Human Macrophages.Semantic proximity Read ↗

Targeting transcription factor Stat4 uncovers a role for interleukin-18 in the pathogenesis of severe lupus nephritis in miceSemantic proximity Read ↗

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