Article
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice.
Nature - 11 Jul 1996
Kaplan M H, Sun Y L, Hoey T, Grusby M J
Abstract excerpt
Interactions between cytokine and receptor lead to the activation of multiple signalling molecules, including the family of signal transducer and activator of transcription (STAT) proteins. STAT4 is one member of this family, and is activated only in response to the cytokine interleukin (IL)-12 (...
Topics
- Animals
- Cell Differentiation
- Cell Line
- Cells, Cultured
- Cytotoxicity, Immunologic
- DNA-Binding Proteins
- Gene Targeting
- Interferon-gamma
- Interleukin-12
- Killer Cells, Natural
- Listeria monocytogenes
- Lymphocyte Activation
- Mice
- Mice, Inbred BALB C
- Mutation
- STAT4 Transcription Factor
- Signal Transduction
- Spleen