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Article

Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development.

Science (New York, N.Y.) - 16 Feb 1996

Güler M L, Gorham J D, Hsieh C S, Mackey A J, Steen R G, Dietrich W F, Murphy K M

Abstract excerpt

The genetic background of T lymphocytes influences development of the T helper (TH) phenotype, resulting in either resistance or susceptibility of certain mouse strains to pathogens such as Leishmania major. With an in vitro model system, a difference in maintenance of responsiveness of T cells to interleukin-12 (IL-12) was detected between BALB/c and B10.D2 mice. Although naive T cells from both strains...

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Identifiers

PMID: 8584935
DOI: 10.1126/science.271.5251.984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development.PMID 8584935Read ↗

T cell genetic background determines maintenance of IL-12 signaling: effects on BALB/c and B10.D2 T helper cell type 1 phenotype development.Semantic proximity Read ↗

The Regulation of Immunity to Leishmania MajorSemantic proximity Read ↗

IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice.Semantic proximity Read ↗

Setting in motion the immune mechanisms underlying genetically determined resistance and susceptibility to infection with Leishmania major.Semantic proximity Read ↗

The murine model of infection with Leishmania major and its importance for the deciphering of mechanisms underlying differences in Th cell differentiation in mice from different genetic backgrounds.Semantic proximity Read ↗

T cell genetic background determines default T helper phenotype development in vitro.Semantic proximity Read ↗

Polarized helper-T-cell responses against Leishmania major in the absence of B cells.Semantic proximity Read ↗

Dendritic cell-derived IL-12p40 homodimer contributes to susceptibility in cutaneous leishmaniasis in BALB/c mice.Semantic proximity Read ↗

BALB/c mice bearing a transgenic IL-12 receptor beta 2 gene exhibit a nonhealing phenotype to Leishmania major infection despite intact IL-12 signaling.Semantic proximity Read ↗

The use of the murine model of infection with Leishmania major to reveal the antagonistic effects that IL-4 can exert on T helper cell development and demonstrate that these opposite effects depend upon the nature of the cells targeted for IL-4 signaling.Semantic proximity Read ↗

Genetic control of interleukin 12 responsiveness: implications for disease pathogenesis.Semantic proximity Read ↗

The capacity to produce IFN-gamma rather than the presence of interleukin-4 determines the resistance and the degree of susceptibility to Leishmania donovani infection in mice.Semantic proximity Read ↗

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