Article
Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development.
Science (New York, N.Y.) - 16 Feb 1996
Güler M L, Gorham J D, Hsieh C S, Mackey A J, Steen R G, Dietrich W F, Murphy K M
Abstract excerpt
The genetic background of T lymphocytes influences development of the T helper (TH) phenotype, resulting in either resistance or susceptibility of certain mouse strains to pathogens such as Leishmania major. With an in vitro model system, a difference in maintenance of responsiveness of T cells t...
Topics
- Animals
- Cells, Cultured
- Coculture Techniques
- Genetic Predisposition to Disease
- Immunity, Innate
- Interferon-gamma
- Interleukin-12
- Interleukin-4
- Leishmania major
- Leishmaniasis, Cutaneous
- Lymphocyte Activation
- Mice
- Mice, Inbred BALB C
- Mice, Transgenic
- Phenotype
- Receptors, Interleukin-2
- Signal Transduction
- Th1 Cells