Article
T helper differentiation proceeds through Stat1-dependent, Stat4-dependent and Stat4-independent phases.
Current topics in microbiology and immunology - 1 Jan 1999
Murphy K M, Ouyang W, Szabo S J, Jacobson N G, Guler M L, Gorham J D, Gubler U, Murphy T L
Abstract excerpt
Much of our focus in understanding Th1/Th2 development has been on the signals delivered by IL-12 and IL-4 as final determinants of terminal T cell differentiation. Because extinction of IL-12 signaling in early Th2 development could potentially be important in imprinting a more permanent Th2 phe...
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