Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

T cell genetic background determines maintenance of IL-12 signaling: effects on BALB/c and B10.D2 T helper cell type 1 phenotype development.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 1997

Güler M L, Jacobson N G, Gubler U, Murphy K M

Abstract excerpt

In this report, we examined the molecular basis underlying the genetic difference between BALB/c and B10.D2 T cells for T helper phenotype development in vitro. We found a strain-dependent difference in early maintenance of IL-12 responsiveness by T cells developing in vitro in unmanipulated (neu...

Topics

Animals
Cells, Cultured
DNA-Binding Proteins
Interferon-gamma
Interleukin-12
Mice
Mice, Inbred BALB C
Phenotype
Phosphorylation
RNA, Messenger
Receptors, Interleukin
Receptors, Interleukin-12

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

STAT4 Transcription Factor

Species Specificity

Th1 Cells

Trans-Activators

Source

Identifiers

PMID: 9257839

Genes

STAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9257839-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

T cell genetic background determines maintenance of IL-12 signaling: effects on BALB/c and B10.D2 T helper cell type 1 phenotype development.PMID 9257839Read ↗

Regulation of interleukin-12 signalling during T helper phenotype development.Semantic proximity Read ↗

Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development.Semantic proximity Read ↗

The IL-4 production capability of different strains of naive CD4+ T cells controls the direction of the Th cell responseSemantic proximity Read ↗

Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses.Semantic proximity Read ↗

T cell genetic background determines default T helper phenotype development in vitro.Semantic proximity Read ↗

Tpm1, a locus controlling IL-12 responsiveness, acts by a cell-autonomous mechanism.Semantic proximity Read ↗

Early Th1/Th2 cell polarization in the absence of IL-4 and IL-12: T cell receptor signaling regulates the response to cytokines in CD4 and CD8 T cells.Semantic proximity Read ↗

A heritable defect in IL-12 signaling in B10.Q/J mice. I. In vitro analysis.Semantic proximity Read ↗

IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice.Semantic proximity Read ↗

BALB/c mice bearing a transgenic IL-12 receptor beta 2 gene exhibit a nonhealing phenotype to Leishmania major infection despite intact IL-12 signaling.Semantic proximity Read ↗

IL-18 induces the differentiation of Th1 or Th2 cells depending upon cytokine milieu and genetic backgroundSemantic proximity Read ↗

Polarized helper-T-cell responses against Leishmania major in the absence of B cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.