Article
Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses.
Proceedings of the National Academy of Sciences of the United States of America - 29 Oct 1996
Gorham J D, Güler M L, Steen R G, Mackey A J, Daly M J, Frederick K, Dietrich W F, Murphy K M
Abstract excerpt
Genetic background of the T cell can influence T helper (Th) phenotype development, with some murine strains (e.g., B10.D2) favoring Th1 development and others (e.g., BALB/c) favoring Th2 development. Recently we found that B10.D2 exhibit an intrinsically greater capacity to maintain interleukin...
Topics
- Animals
- Chromosome Mapping
- Chromosomes
- Chromosomes, Human, Pair 5
- Female
- Humans
- Interleukin-12
- Male
- Mice
- Mice, Inbred BALB C
- Phenotype
- Polymorphism, Restriction Fragment Length
- Th1 Cells
- Th2 Cells