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Article

Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses.

Proceedings of the National Academy of Sciences of the United States of America - 29 Oct 1996

Gorham J D, Güler M L, Steen R G, Mackey A J, Daly M J, Frederick K, Dietrich W F, Murphy K M

Abstract excerpt

Genetic background of the T cell can influence T helper (Th) phenotype development, with some murine strains (e.g., B10.D2) favoring Th1 development and others (e.g., BALB/c) favoring Th2 development. Recently we found that B10.D2 exhibit an intrinsically greater capacity to maintain interleukin 12 (IL-12) responsiveness under neutral conditions in vitro compared with BALB/c T cells, allowing for prolonged...

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Identifiers

PMID: 8901605
DOI: 10.1073/pnas.93.22.12467
PMCID: PMC38015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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