Tpm1, a locus controlling IL-12 responsiveness, acts by a cell-autonomous mechanism.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Tpm1, a locus controlling IL-12 responsiveness, acts by a cell-autonomous mechanism.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1999

Guler M L, Gorham J D, Dietrich W F, Murphy T L, Steen R G, Parvin C A, Fenoglio D, Grupe A, Peltz G, Murphy K M

Abstract excerpt

Th phenotype development is controlled not only by cytokines but also by other parameters including genetic background. One site of genetic variation between murine strains that has direct impact on Th development is the expression of the IL-12 receptor. T cells from B10.D2 and BALB/c mice show d...

Topics

Alleles
Animals
Base Sequence
CD4-Positive T-Lymphocytes
Chromosome Mapping
Crosses, Genetic
DNA Primers
Female
Genetic Linkage
Genetic Markers
Genotype
Interleukin-12

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Inbred BALB C

Mice, Transgenic

Phenotype

Receptors, Antigen, T-Cell, alpha-beta

Source

Open in PubMed

Identifiers

PMID: 9973388

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9973388-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tpm1, a locus controlling IL-12 responsiveness, acts by a cell-autonomous mechanism.PMID 9973388Read ↗

Regulation of interleukin-12 signalling during T helper phenotype development.Semantic proximity Read ↗

Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses.Semantic proximity Read ↗

Early Th1/Th2 cell polarization in the absence of IL-4 and IL-12: T cell receptor signaling regulates the response to cytokines in CD4 and CD8 T cells.Semantic proximity Read ↗

Genetic control of interleukin 12 responsiveness: implications for disease pathogenesis.Semantic proximity Read ↗

IL-TIF/IL-22: genomic organization and mapping of the human and mouse genesSemantic proximity Read ↗

Molecular Mechanisms RegulatinG Th1 Immune ResponsesSemantic proximity Read ↗

T cell genetic background determines maintenance of IL-12 signaling: effects on BALB/c and B10.D2 T helper cell type 1 phenotype development.Semantic proximity Read ↗

TH2 cell development and functionSemantic proximity Read ↗

In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitmentSemantic proximity Read ↗

Blimp-1 Contributes to the Development and Function of Regulatory B CellsSemantic proximity Read ↗

Signaling from cytokine receptors that affect TH1 responsesSemantic proximity Read ↗

T-cell–intrinsic Tif1α/Trim24 regulates IL-1R expression on T H 2 cells and T H 2 cell-mediated airway allergySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.