Article
Tpm1, a locus controlling IL-12 responsiveness, acts by a cell-autonomous mechanism.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1999
Guler M L, Gorham J D, Dietrich W F, Murphy T L, Steen R G, Parvin C A, Fenoglio D, Grupe A, Peltz G, Murphy K M
Abstract excerpt
Th phenotype development is controlled not only by cytokines but also by other parameters including genetic background. One site of genetic variation between murine strains that has direct impact on Th development is the expression of the IL-12 receptor. T cells from B10.D2 and BALB/c mice show distinct control of IL-12 receptor expression. When activated by Ag, B10.D2 T cells express functional IL-12 receptors...
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