Article
Immunization with a replication-deficient mutant of herpes simplex virus type 1 (HSV-1) induces a CD8+ cytotoxic T-lymphocyte response and confers a level of protection comparable to that of wild-type HSV-1.
Journal of virology - 1 May 1997
Brehm M A, Bonneau R H, Knipe D M, Tevethia S S
Abstract excerpt
Replication-deficient viruses provide an attractive alternative to conventional approaches used in the induction of antiviral immunity. We have quantitatively evaluated both the primary and memory cytotoxic T-lymphocyte (CTL) responses elicited by immunization with a replication-deficient mutant...
Topics
- Animals
- CD4-Positive T-Lymphocytes
- Cell Line
- Herpes Simplex
- Herpesvirus 1, Human
- Immunization
- Lymph Nodes
- Male
- Mice
- Mice, Inbred C57BL
- Mutation
- T-Lymphocytes, Cytotoxic
- Virus Replication