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Replication-deficient mutant Herpes Simplex Virus-1 targets professional antigen presenting cells and induces efficient CD4+ T helper responses.

Microbes and infection - 1 Jul 2007

Fiorentini Simona, Marconi Peggy, Avolio Manuela, Marini Elena, Garrafa Emirena, Caracciolo Sonia, Rossi Daniele, Bozac Alexandra, Becker Pablo D, Gentili Francesca, Facchetti Fabio, Guzman Carlos A, Manservigi Roberto, Caruso Arnaldo

Abstract excerpt

Both neutralizing antibodies and cytotoxic T-cells are necessary to control a viral infection. However, vigorous T helper responses are essential for their elicitation and maintenance. Here we show that a recombinant replication-deficient Herpes Simplex Virus (HSV)-1 vector encoding the Human Immunodeficiency Virus (HIV)-1 matrix protein p17 (T0-p17) was capable of infecting professional antigen presenting cells...

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Share to Antigen-Presenting Cells
Share to gag Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17553721
DOI: 10.1016/j.micinf.2007.04.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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