Article
Composite response of naive T cells to stimulation with the autologous lymphoblastoid cell line is mediated by CD4 cytotoxic T cell clones and includes an Epstein-Barr virus-specific component.
Cellular immunology - 1 Feb 1991
Misko I S, Sculley T B, Schmidt C, Moss D J, Soszynski T, Burman K
Abstract excerpt
We have approached the challenge of generating a primary T cell response to Epstein-Barr virus (EBV) in vitro by stimulating naive T cells with the autologous EBV-transformed lymphoblastoid cell line (LCL), a rich source of EBV-associated cytotoxic T lymphocyte (CTL) epitopes. Responsive T cells...
Topics
- Antigens, Differentiation, T-Lymphocyte
- Antigens, Viral
- CD4 Antigens
- CD8 Antigens
- Cell Line
- Clone Cells
- Cytotoxicity, Immunologic
- Epstein-Barr Virus Nuclear Antigens
- Herpesvirus 4, Human
- Humans
- Immunoblotting
- Killer Cells, Natural
- Phenotype
- T-Lymphocytes, Cytotoxic