Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antibodies Are Required for Complete Vaccine-Induced Protection against Herpes Simplex Virus 2.

PloS one - 1 Jan 2015

Halford William P, Geltz Joshua, Messer Ronald J, Hasenkrug Kim J

Abstract excerpt

Herpes simplex virus 2 (HSV-2) 0ΔNLS is a live HSV-2 ICP0- mutant vaccine strain that is profoundly attenuated in vivo due to its interferon-hypersensitivity. Recipients of the HSV-2 0ΔNLS vaccine are resistant to high-dose HSV-2 challenge as evidenced by profound reductions in challenge virus spread, shedding, disease and mortality. In the current study, we investigated the requirements for HSV-2 0ΔNLS...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Eye
Share to Herpes Genitalis
Share to Herpesvirus 2, Human

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immune Sera

Share to Immunization

Share to Immunization, Passive

Share to Nuclear Localization Signals

Share to Vagina

Source

Open in PubMed Open full text

Identifiers

PMID: 26670699
DOI: 10.1371/journal.pone.0145228
PMCID: PMC4682860

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antibodies Are Required for Complete Vaccine-Induced Protection against Herpes Simplex Virus 2.PMID 26670699Read ↗

A Live-Attenuated HSV-2 ICP0− Virus Elicits 10 to 100 Times Greater Protection against Genital Herpes than a Glycoprotein D Subunit VaccineSemantic proximity Read ↗

Herpes simplex virus 2 ICP0 mutant viruses are avirulent and immunogenic: implications for a genital herpes vaccine.Semantic proximity Read ↗

Immunization against genital herpes with a vaccine virus that has defects in productive and latent infectionSemantic proximity Read ↗

Immunization with a replication-defective herpes simplex virus 2 mutant reduces herpes simplex virus 1 infection and prevents ocular disease.Semantic proximity Read ↗

Deletion of immune evasion genes provides an effective vaccine design for tumor-associated herpesvirusesSemantic proximity Read ↗

Deletion of immune evasion genes provides an effective vaccine design for tumor-associated herpesvirusesSemantic proximity Read ↗

Attenuated Herpes Simplex Virus 1 (HSV-1) Expressing a Mutant Form of ICP6 Stimulates a Strong Immune Response That Protects Mice against HSV-1-Induced Corneal Disease.Semantic proximity Read ↗

Immunization with Herpes Simplex Virus Nanoparticles Targeting Both Attachment and Fusion Protect Against InfectionSemantic proximity Read ↗

A Herpes Simplex Virus Type-1-derived influenza vaccine induces balanced adaptive immune responses and protects mice from lethal influenza virus challengeSemantic proximity Read ↗

Antigenic breadth: a missing ingredient in HSV-2 subunit vaccines?Semantic proximity Read ↗

A Novel DNA Vaccine Technology Conveying Protection against a Lethal Herpes Simplex Viral Challenge in MiceSemantic proximity Read ↗

Recent advances in vaccine development for herpes simplex virus types I and IISemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.