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Article

Replication-defective mutants of herpes simplex virus (HSV) induce cellular immunity and protect against lethal HSV infection.

Journal of virology - 1 Dec 1992

Nguyen L H, Knipe D M, Finberg R W

Abstract excerpt

Live viruses and live virus vaccines induce cellular immunity more readily than do inactivated viruses or purified proteins, but the mechanism by which this process occurs is unknown. A trivial explanation would relate to the ability of live viruses to spread and infect more cells than can inactivated virus. We have used live but replication-defective mutants to investigate this question. Our studies indicate...

Topics

Animals
DNA-Binding Proteins
Female
Gene Deletion
Genes, Viral
Immediate-Early Proteins
Immunity, Cellular
Mice
Mice, Inbred BALB C
Mutation
Simplexvirus
Spleen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocytes

Vero Cells

Viral Proteins

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 1331509
DOI: 10.1128/JVI.66.12.7067-7072.1992
PMCID: PMC240374

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1331509-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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