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Attenuated Herpes Simplex Virus 1 (HSV-1) Expressing a Mutant Form of ICP6 Stimulates a Strong Immune Response That Protects Mice against HSV-1-Induced Corneal Disease.

Journal of virology - 1 Sept 2018

Davido David J, Tu Eleain M, Wang Hong, Korom Maria, Gazquez Casals Andreu, Reddy P Jahnu, Mostafa Heba H, Combs Benjamin, Haenchen Steve D, Morrison Lynda A

Abstract excerpt

We previously isolated a herpes simplex virus 1 (HSV-1) mutant, KOS-NA, that carries two nonsynonymous mutations in UL39, resulting in L393P and R950H amino acid substitutions in infected cell protein 6 (ICP6). Our published data studying KOS-NA pathogenesis strongly suggest that one of these ICP6 substitutions expressed from KOS-NA, R950H, severely impaired acute viral replication in the eyes and trigeminal...

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Identifiers

PMID: 29950407
DOI: 10.1128/JVI.01036-18
PMCID: PMC6096795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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