Article
Protective vaccination against primary and recurrent disease caused by herpes simplex virus (HSV) type 2 using a genetically disabled HSV-1.
The Journal of infectious diseases - 1 Nov 1994
McLean C S, Erturk M, Jennings R, Challanain D N, Minson A C, Duncan I, Boursnell M E, Inglis S C
Abstract excerpt
The vaccine potential of a mutant herpes simplex virus (HSV) type 1, with a deletion in the glycoprotein H (gH) gene, was evaluated. The virus requires a gH-expressing cell line for multi-cycle growth but can complete a single cycle of infection in noncomplementing cells. Such viruses, termed DIS...
Topics
- Animals
- Antibodies, Viral
- Female
- Guinea Pigs
- Herpes Genitalis
- Herpesvirus 1, Human
- Mutation
- Recurrence
- Vaccination
- Viral Vaccines
- Virus Replication