Immunization with a replication-defective herpes simplex virus 2 mutant reduces herpes simplex virus 1 infection and prevents ocular disease.

doi:10.1016/j.virol.2007.08.030

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Article

Immunization with a replication-defective herpes simplex virus 2 mutant reduces herpes simplex virus 1 infection and prevents ocular disease.

Virology - 25 Nov 2007

van Lint Allison L, Torres-Lopez Ernesto, Knipe David M

Abstract excerpt

Ocular infections with herpes simplex virus 1 can lead to corneal scarring and blindness, with herpes keratitis being the major infectious cause of blindness. There is currently no clinically approved vaccine and nearly all developmental vaccines are targeted against HSV-2 and genital herpes. We tested the ability of an HSV-2 replication-defective virus, a genital herpes vaccine candidate, to protect against...

Topics

Animals
Defective Viruses
Herpesvirus 1, Human
Herpesvirus 2, Human
Herpesvirus Vaccines
Immunization
Keratitis, Herpetic
Male
Mice
Mutation
Virus Latency
Virus Replication

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Open in PubMed Open full text

Identifiers

PMID: 17915278
DOI: 10.1016/j.virol.2007.08.030
PMCID: PMC2099303

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