Article
Protection from bacterial infection by a single vaccination with replication-deficient mutant herpes simplex virus type 1.
Journal of virology - 1 Apr 2004
Lauterbach Henning, Kerksiek Kristen M, Busch Dirk H, Berto Elena, Bozac Aleksandra, Mavromara Penelope, Manservigi Roberto, Epstein Alberto L, Marconi Peggy, Brocker Thomas
Abstract excerpt
Adaptive immune responses in which CD8(+) T cells recognize pathogen-derived peptides in the context of major histocompatibility complex class I molecules play a major role in the host defense against infection with intracellular pathogens. Cells infected with intracellular bacteria such as Listeria monocytogenes, Salmonella enterica serovar Typhimurium, or Mycobacterium tuberculosis are directly lysed by...
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