Article
The role of Sas2, an acetyltransferase homologue of Saccharomyces cerevisiae, in silencing and ORC function.
Genetics - 1 Apr 1997
Ehrenhofer-Murray A E, Rivier D H, Rine J
Abstract excerpt
Silencing at the cryptic mating-type loci HML and HMR of Saccharomyces cerevisiae requires regulatory sites called silencers. Mutations in the Rap1 and Abf1 binding sites of the HMR-E silencer (HMRa-e**) cause the silencer to be nonfunctional, and hence, cause derepression of HMR. Here, we have isolated and characterized mutations in SAS2 as second-site suppressors of the silencing defect of HMRa-e**. Silencing...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.