Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases.

doi:10.1038/ng0996-42

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Article

Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases.

Nature genetics - 1 Sept 1996

Reifsnyder C, Lowell J, Clarke A, Pillus L

Abstract excerpt

Silencing is an epigenetic form of transcriptional regulation whereby genes are heritably, but not necessarily permanently, inactivated. We have identified the Saccharomyces cerevisiae genes SAS2 and SAS3 through a screen for enhancers of sir1 epigenetic silencing defects. SAS2, SAS3 and a Schizosaccharomyces pombe homologue are closely related to several human genes, including one associated with acute myeloid...

Topics

Acetyltransferases
Acute Disease
Amino Acid Sequence
Base Sequence
Cloning, Molecular
DNA, Fungal
Enhancer Elements, Genetic
Fungal Proteins
Gene Expression Regulation, Fungal
Gene Products, tat
HIV-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Leukemia, Myeloid

Molecular Sequence Data

Mutation

Phenotype

Resting Phase, Cell Cycle

Saccharomyces cerevisiae

Source

Open in PubMed

Identifiers

PMID: 8782818
DOI: 10.1038/ng0996-42

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases.PMID 8782818Read ↗

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The silencing complex SAS-I links histone acetylation to the assembly of repressed chromatin by CAF-I and Asf1 in Saccharomyces cerevisiae.Semantic proximity Read ↗

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