Article
The silencing complex SAS-I links histone acetylation to the assembly of repressed chromatin by CAF-I and Asf1 in Saccharomyces cerevisiae.
Genes & development - 1 Dec 2001
Meijsing S H, Ehrenhofer-Murray A E
Abstract excerpt
The acetylation state of histones plays a central role in determining gene expression in chromatin. The reestablishment of the acetylation state of nucleosomes after DNA replication and chromatin assembly requires both deacetylation and acetylation of specific lysine residues on newly incorporated histones. In this study, the MYST family acetyltransferase Sas2 was found to interact with Cac1, the largest subunit...
Topics
- Acetyl Coenzyme A
- Acetylation
- Acetyltransferases
- Binding Sites
- Blotting, Western
- Cell Cycle Proteins
- Chromatin
- Chromatin Assembly Factor-1
- Chromosomal Proteins, Non-Histone
- DNA, Fungal
- DNA, Ribosomal
- DNA-Binding Proteins
- Gene Deletion