Article
Identification of SAS4 and SAS5, two genes that regulate silencing in Saccharomyces cerevisiae.
Genetics - 1 Sept 1999
Xu E Y, Kim S, Replogle K, Rine J, Rivier D H
Abstract excerpt
In Saccharomyces cerevisiae, chromatin-mediated silencing inactivates transcription of the genes at the HML and HMR cryptic mating-type loci and genes near telomeres. Mutations in the Rap1p and Abf1p binding sites of the HMR-E silencer (HMRa-e**) result in a loss of silencing at HMR. We characterized a collection of 15 mutations that restore the alpha-mating phenotype to MATalpha HMRa-e** strains. These mutations...
Topics
- Amino Acid Sequence
- Binding Sites
- DNA-Binding Proteins
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Genes, Mating Type, Fungal
- Genetic Complementation Test
- Humans
- Leukemia, Myelomonocytic, Acute